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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IRAK1 All Species: 13.33
Human Site: S137 Identified Species: 32.59
UniProt: P51617 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51617 NP_001020413.1 712 76537 S137 W S P R K L P S S A S T F L S
Chimpanzee Pan troglodytes XP_521332 850 89683 S278 W S P R K L P S S A S T L L S
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_549367 722 76996 T137 P R P R K L P T A S A S T L P
Cat Felis silvestris
Mouse Mus musculus Q62406 710 77251 S137 W S P R K L Q S S A S T F L S
Rat Rattus norvegicus Q4QQS0 624 69218 P97 V L S W K P A P D S L S P L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508862 872 94244 S223 P S P G P G P S Q G D T A T M
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_697688 686 76453 R129 P E I R P L P R P S P P P P D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002312803 404 44281
Maize Zea mays NP_001132095 412 44547
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q06548 410 45501
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 77.1 N.A. 83 N.A. 81 27.6 N.A. 49.4 N.A. N.A. 36.3 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 78.9 N.A. 87.8 N.A. 85.2 44.9 N.A. 59 N.A. N.A. 52.5 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 93.3 N.A. 40 N.A. 93.3 20 N.A. 33.3 N.A. N.A. 20 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 93.3 N.A. 73.3 N.A. 93.3 33.3 N.A. 33.3 N.A. N.A. 26.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: 23.8 25.8 N.A. 22.8 N.A. N.A.
Protein Similarity: 33 36.2 N.A. 35.3 N.A. N.A.
P-Site Identity: 0 0 N.A. 0 N.A. N.A.
P-Site Similarity: 0 0 N.A. 0 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 10 0 10 30 10 0 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 10 0 10 0 0 0 10 % D
% Glu: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 20 0 0 % F
% Gly: 0 0 0 10 0 10 0 0 0 10 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 50 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 10 0 0 0 50 0 0 0 0 10 0 10 50 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 30 0 50 0 20 10 50 10 10 0 10 10 20 10 10 % P
% Gln: 0 0 0 0 0 0 10 0 10 0 0 0 0 0 0 % Q
% Arg: 0 10 0 50 0 0 0 10 0 0 0 0 0 0 0 % R
% Ser: 0 40 10 0 0 0 0 40 30 30 30 20 0 0 40 % S
% Thr: 0 0 0 0 0 0 0 10 0 0 0 40 10 10 0 % T
% Val: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 30 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _